Too much Protein in Urine
What does Too much Protein in Urine mean?
Too much protein in urine is defined as the total protein in urine >3.5g /24h. There is often a good correlation between the severity of glomerulonephritis and the degree of "protein in urine". Glomerulonephritis is the renal glomerular inflammation, that destroys your kidney filtration system to allow large amounts of protein into the urine. Therefore, "too much protein in urine" often means that you have a severe glomerulonephritis.
Due to large amount of proteins have been excreted into the urine, your liver will produce more protein to compensate for the protein loss. However, the loss can often exceed the supplement, and therefore, you get a low protein in blood. In addition, well known, patients with kidney disease often have varying degrees of edema, that affects your eyelid, face, lower limb, even the whole body. When stomach and bowel are affected, you lose your appetite and the gastrointestinal function will also be reduced. So, food protein intake and absorption are affected. You lack protein more.
When albumin in blood <30g /L, and you also have too much protein in urine, your condition will be diagnosed as the so-called "nephrotic syndrome".
What causes Too much protein in urine?
Any disease which causes glomerular damage may lead to too much protein in urine. Theses diseases or disorders include glomerular nephropathy, glomerulonephritis, diabetes, SLE, allergic purpura, amyloidosis, malignant hypertension, hardening of the arteries of kidney, renal vein thrombosis, and other causes of nephrotic syndrome.
Glomerulus is an important structure of the kidney, consisting of a cluster of capillaries, in which matters are selectively filtered out. Normally, glomeruli can prevent the passing of protein from blood into urine, so that there is only a trace of protein in urine.
If the glomeruli are severely damaged due to inflammation and damage in glomerulus and its tiny blood vessels of kidneys, in this case, large amounts of protein and macromolecular proteins will leak out of the blood through the kidney into the urine. Thus, the result is too much protein in urine.
In most cases, Too much protein in urine (>3.5g /d) is also known as nephrotic syndrome, which is a set of symptoms occurring together due to affecting the kidney glomeruli (filtration system of kidney).
Too much protein in urine is one of the two essential diagnostic criteria of nephrotic syndrome, and the other is the serum albumin less than 30g / L. The latter is often the inevitable result of too much blood protein loss in the urine.
Causes of nephrotic syndrome/ too much protein in urine in detail:
- Minimal change nephropathy/ or minimal-change nephrotic syndrome (MCNS)
- Mesangial proliferative glomerulonephritis
- Mesangial capillary glomerulonephritis
- Focal segmental glomerulosclerosis
- Membranous nephropathy
- Diabetic Nephropathy
- Renal amyloidosis
- Myeloma-related nephropathy
- Lymphoma-related nephropathy
- Henoch-Schonlein purpura nephritis
- Systemic lupus erythematosus nephritis
- Hepatitis-related glomerulonephritis
- Hereditary nephrotic syndrome
Last update: 2012-08-16